Regional Interdependence

I am very excited that Dr. Brence invited me to join him here at He has a great blog with lots of wonderful content. My first few posts are going to be recycled from my bog, which I am shutting down.
I recently read an article by Muth et al which looked at the effects of thoracic spine thrust manipulation on patients with signs of rotator cuff pathology. This study utilizes the concept of regional interdependence which has gained popularity over the last several years. This theory suggests that pain and dysfunction in one area of the body can be treated with interventions to adjacent regions. This concept is not new, however more recent studies have fueled its increased popularity by providing support for it. For example, treatment of the hip is thought to have an impact on knee and low back pain, and treatment aimed at the thoracic spine as been shown to have effects on shoulder and neck pain. These effects are often explained based on biomechanics however, the exact mechanism is still unclear.  It is possible that some of these effects can be explained by changes in biomechanics, although there are a few reasons why I remain skeptical about this explanation . First, many of these studies use manual therapy and chainexercise as an intervention. It is assumed that these interventions have an impact on the biomechanics of a joint however this hypothesis remains unproven. The often immediate effects of manual therapy may suggest that its actions go further than just local changes to a joint.  Although possible, I would not expect small changes in biomechanics at one joint to immediately result in reduced pain and improved function at a distant joint. It seems more plausible that a change in the nervous system (increased pain threshold etc.) would be more likely to result in this immediate effect.  If we consider exercises to either strengthen or stretch a muscle it may theoretically change biomechanics, however there are few examples of this in the literature.   The other major reason I am skeptical of the biomechanical explanation for regional interdependence is the consistent failure of studies to find a strong connection between biomechanical factors and patient symptoms. Even in cases where a correlation between mechanics and symptoms has been documented (for example shoulder pain and scapular dyskinesia) it is often unclear if the changes in biomechanics are the cause or a result of the problem.
The study by Muth et al built off other studies (here and here) which found a reduction in shoulder pain after thoracic spine manipulation (TSM). The goal of this study was to try and determine a mechanism for the reduction in shoulder pain after TSM. The authors took 30 subjects with shoulder pain and put them through a battery of tests including: scapular kinematic testing (using electromagnetic tracking), EMG (infraspinatus, upper/middle/lower trap, serratus), pain rating (during empty can test, Hawkins-Kennedy test,  Neer test and loaded elevation),  peak shoulder elevation force and a few shoulder function questionnaires.
As with previous studies they found a reduction in pain and an improvement in function after the TSM. This reduction in pain was not associated with changes in biomechanics. The only statistical significant change in scapular motion was a reduction in upward rotation after the TSM. Based on current thinking we would expect a reduction in upward rotation to decrease the subacromial space, result in more pressure on the cuff and cause increased pain.  At this point you are probably thinking “but what about thoracic motion”. Good thought but no, that did not change either.
The results of this study calls into question the biomechanical explanation for the improvements found after TSM.  I would not suggest that regional interdependence is never a result of biomechanical changes, however we should be careful not to assume the mechanism is biomechanical. It is important for us to consider the mechanism behind regional interdependence because often our understanding of mechanism dictates how we use the intervention. For example, TSM may not be used in a patient with shoulder pain who is found to have a normal or hypermobile thoracic spine. We assume that TSM is only effective in patients with a stiff thoracic spine because we believe the mechanism of action is increased thoracic extension (or motion in general).  If the patient has good extension with no stiffness there would be no reason to perform a TSM.  If we understand that the mechanism behind TSM may not be mechanical, we would avoid using only mechanical findings to dictate whether we performed a TSM or not.  At this point, all we know is that the presence of shoulder pain is an indication that TSM may be helpful.Shoulder
Another important issue to address about the Muth et al study (and many other studies looking at manual therapy) is that there was no sham treatment group. The absence of a sham treatment group makes it impossible to determine whether the benefits from TSM were due to a specific effect or a result of non-specific effects such as placebo or patient expectation.
To sum things up, TSM seems to provide short term improvements in pain and function for patients with shoulder pain. The mechanism behind these improvements does not appear to be biomechanical. We need more studies looking into the mechanism behind this, and other examples of regional interdependence, so we can more accurately match interventions to patients.


All Comments

  • What to say but I agree wholehearthedly!

    Frédéric Wellens, pht, Canadian Intermediate Diploma in Manual Therapy March 16, 2013 9:24 am Reply
  • Welcome to the blogosphere Adam! Great post here on TSM. I would say that I find better results (short term at least) with TSM for shoulder pain if I detect hypomobility (yes, subjective) and/or a forward head/rounded shoulders so I def wouldn’t discount using this data as a reason to perform this intervention.
    Looking forward to more insights on mechanisms of manual therapy.

    Harrison Vaughan March 16, 2013 12:23 pm Reply
  • Harrison,
    Thanks for the welcome and thank you for sharing your experience. I agree that this data does not provide insight into whether TSM is an effective treatment for shoulder pain. However, if it is effective, based on this data it seems unlikely that it is from biomechanical changes.
    I have not observed that hypomobility and forward head/rounded shoulders predicts successful outcomes with TSM for shoulder pain, however maybe I missed it. I am a bit doubtful of the connection simply because the position of the thoracic spine and scapula are not related to shoulder pain. Increased thoracic extension may allow people with shoulder pain to get more elevation, however I am not sure that TSM can increase thoracic extension.

    Adam Rufa March 16, 2013 1:03 pm Reply
    • It’s an horrible answer how are regions interdependent wow that’s just the worst thing ever no information

      Olivia November 3, 2014 6:15 pm
  • Hi Adam, welcome to the online PT world.. (although I’m not PT per se, so not sure if that welcome is valid..). Gradually starting to venture further into evidence based practice to inform my osteopathic practice life, and was interested in your article, although not being able to read the entire article by Muth leaves me with a few questions:
    – do we know which levels were manipulated and whether that made a difference?
    – do we know which technique was used for the actual manipulation? there are a few that I would not use on patients with RCT.
    – I’ve been trying to think of whether I’ve ever decided to use TSM for patients with RCT, and can’t recall any, probably because I’ve never come across a patient where I thought the tsp hypomobility was linked to the onsent of RCT, regardless of mechanism… Would be interesting to look at whether similar interventions have higher effect for different kinds of shoulder pain though.
    I would argue that tsp and scapular position can be related to shoulder pain; just not necessarily, it depends on the pain / diagnosis / pain causing tissues, etc. Pretty much agree that TSM can’t increase overall Tsp Extension range though, articulation and exercsies would be better for that.

    Osteopathy Aotearoa (@OsteoNZ) March 22, 2013 12:33 am Reply
  • Thanks for the welcome Phil, even if you are a DO :).
    1) mid and upper thoracic spine.
    2) Seated distraction
    3) There are a few studies (noted above) which showed improvement in patients with shoulder pain after TSM. The mechanism is unclear however it is doubtful that it is based on biomechanics or mobility. I don’t think that thoracic hypomobility predicts whether someone will respond well to TSM (for any condition).
    “I would argue that tsp and scapular position can be related to shoulder pain; just not necessarily,” You may be correct however the evidence indicates the opposite. There are several studies which show posture of the scapula, thoracic spine and neck are not related to shoulder pain (surprising isn’t it). I will do a post on this topic in the future.

    Adam Rufa March 22, 2013 9:17 pm Reply

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